GFRE is traditionally considered the best overall index to determine renal function in health and disease, being Cockcroft y Gault formula more widely used to predict it. Recently MDRD study developed a new formula, more accurate to evaluate GFR, based on age, sex, gender,height, serum creatinin, serum BUN and serum Albumin. But this study has not been tested in elderly and diabetic patients with CRI.The performance of GFR derived from MDRD in subgroup of diabetics and elderly patients with CRI and compare with others indexes was the aim of the study.
23 pts diabetics were studied in our PreESRD unit Mean age ( x¯)= 71.09 ± 12.68 yr, 12 M, 11 W, included with CrClbs <30 ml/min/1.73m2 . ICDE 2.57±0.79. Parameters analyzed were , age, gender, weight, sex, height, serum Cr, serum Albumina , serum BUN, urine BUN, urine Cr , diuresis and proteinuria. Data were processed and stadistically analyzed with SPSS 10.0 software package. The relation of renal function measurements to other baseline characteristics was assessed by using contingency tables, t-tests, analysis of variance and linear regression, as appropiate. A P value less than 0.01 was considered statistically significant. We used stepwise multiple regression to determine a set of variables that predicted GFR.
Descriptive parameters of renal function were:
Linear regression results were